New aspects of the role of MR/P fimbriae in Proteus mirabilis urinary tract infection.
FEMS Immunol Med Microbiol
; 31(2): 113-20, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11549418
ABSTRACT
Proteus mirabilis, a common cause of urinary tract infection (UTI), produces a number of different fimbriae including mannose-resistant Proteus-like fimbriae (MR/P). The precise role of different P. mirabilis fimbriae in ascending UTI has not yet been elucidated. In this study, a clinical isolate of P. mirabilis and an isogenic mutant unable to express MR/P were tested using different experimental approaches. They were tested for their ability to cause infection in an ascending co-infection model of UTI and in a haematogenous model in the mouse. In both models, the mutant was less able than the wild-type strain to colonise the lower and upper urinary tracts although infectivity was not abolished. In vitro adherence to uroepithelial cells was also assessed. Significant differences in adherence between both strains were observed at 1 h but not at 15 min post infection. We have also shown that a wild-type strain carries two copies of the mrpA gene. These data reinforce the importance of MR/P fimbriae in P. mirabilis UTI although other virulence factors may be necessary for efficient colonisation and development of infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Proteus
/
Proteus mirabilis
/
Infecções Urinárias
/
Fímbrias Bacterianas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
FEMS Immunol Med Microbiol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Uruguai