Role of angiotensin type 2 receptors in human forearm vascular responses of normal volunteers.
Clin Exp Pharmacol Physiol
; 28(9): 734-6, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11553032
ABSTRACT
1. It has been hypothesized that the expression of angiotensin (Ang) II type 2 (AT(2)) receptors may become important in vascular disease; however, the functional existence of AT(2) receptors in normal adult humans remains to be established. 2. Vascular responses to AngII after the administration of the specific AT(2) receptor antagonist PD 123319 were determined in the forearm circulation of normal volunteers. 3. PD 123319 (8 microg/min) did not alter basal forearm blood flow, or forearm blood flow or forearm vascular resistance responses to AngII. 4. These results suggest that AT(2) receptors do not play a significant role in the regulation of forearm blood flow or forearm vascular resistance of normal volunteers, but do not preclude a role for AT(2) receptors in other vascular beds or in patients with cardiovascular disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Angiotensina
/
Antebraço
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Austrália