Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole.

Mosquera, J; Warn, P A; Rodriguez-Tudela, J L; Denning, D W

Mosquera, J; Warn, P A; Rodriguez-Tudela, J L; Denning, D W.

Afiliação

Mosquera J; School of Medicine, Section of Infectious Diseases, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, UK.

J Antimicrob Chemother ; 48(4): 583-6, 2001 Oct.

Article em En | MEDLINE | ID: mdl-11581243

ABSTRACT

ABSTRACT

The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

Assuntos

Absidia/efeitos dos fármacos; Anfotericina B/uso terapêutico; Antifúngicos/uso terapêutico; Itraconazol/uso terapêutico; Mucormicose/tratamento farmacológico; Absidia/classificação; Animais; Modelos Animais de Doenças; Humanos; Masculino; Camundongos; Testes de Sensibilidade Microbiana/métodos; Mucormicose/microbiologia

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anfotericina B / Itraconazol / Absidia / Mucormicose / Antifúngicos Limite: Animals / Humans / Male Idioma: En Revista: J Antimicrob Chemother Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Reino Unido

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