[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage]. / Farmakoterapevticheskii éffekt fitoékdisteroidov i nerobola pri toksicheskom porazhenii pochek v éksperimente.

ABSTRACT

Phytoecdysteroids ecdysteron and turkesteron isolated from Ajuga turkestanica (Rgl.) Brig. decrease the manifestations of uremic intoxication in rats with experimental renal pathology induced by a nephrotoxic mixture (containing uranyl acetate and glycerol). Injected in a dose of 5 mg/kg, the drugs restore glomerular filtration level, favor the disappearance of the albuminuria and normalize urinary sediments. The nephroprotector effect of the phytoecdysteroids studied resembles the action of a steroidal anabolic drug nerobol.