Cutaneous T-cell lymphoma in a cardiac transplant recipient.
Tex Heart Inst J
; 28(3): 203-7, 2001.
Article
em En
| MEDLINE
| ID: mdl-11678256
ABSTRACT
Mycosis fungoides, an uncommon form of cutaneous T-cell lymphoma, arises in the skin and frequently progresses to generalized lymphadenopathy Although the cause of cutaneous T-cell lymphoma is unknown, chronic immunosuppression may play a role. A few cases have been reported in renal transplant recipients; however, ours appears to be the 1st report of cutaneous T-cell lymphoma in a cardiac transplant recipient. In our patient, cutaneous manifestations of the disease were noted less than 1 year after transplantation. Seven years after transplantation, Sézary syndrome, a variant form of mycosis fungoides, was diagnosed by tissue biopsy and flow cytometry analysis. Photopheresis improved symptoms but was not well tolerated because of hemodynamic sequelae. Psoralen and ultraviolet A therapy also improved the patient's skin condition, but a generalized lymphadenopathy developed. The maintenance immunosuppressive regimen was changed from cyclosporine (3 mg/kg/day) and azathioprine to cyclosporine (1.5 mg/kg/day) and cyclophosphamide. Although effective in the short-term, the results of this therapeutic strategy could not be fully evaluated because the patient died of acute myocardial infarction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Transplante de Coração
/
Terapia de Imunossupressão
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Micose Fungoide
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Imunossupressores
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Tex Heart Inst J
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos