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Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity.
Lee, S Y; Huang, C K; Zhang, T F; Schofield, B H; Burks, A W; Bannon, G A; Sampson, H A; Li, X M.
Afiliação
  • Lee SY; Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA.
Clin Immunol ; 101(2): 220-8, 2001 Nov.
Article em En | MEDLINE | ID: mdl-11683581
ABSTRACT
There is no satisfactory therapeutic intervention for peanut allergy, which accounts for most life-threatening food allergic reactions. Since IL-12 has been found to inhibit allergic airway responses in a mouse model of asthma and to cure Th2 cytokine-mediated murine schistosomiasis, we hypothesized that IL-12 treatment might also inhibit peanut allergic reactions. Consequently, we investigated the effects of oral IL-12 treatment in a murine model of peanut allergy and found that oral administration of liposome encapsulated rIL-12 could both prevent and reverse peanut hypersensitivity and could reduce histamine release, peanut-specific serum IgE and IgG1, and fecal IgA levels. Oral IL-12 treatment also increased IFN-gamma but did not decrease IL-4 or IL-5 levels. We conclude that oral rIL-12 treatment has therapeutic as well as preventive effects on peanut allergy, which are associated with increased IFN-gamma production.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-12 / Hipersensibilidade a Amendoim / Anafilaxia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-12 / Hipersensibilidade a Amendoim / Anafilaxia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Estados Unidos