Does stress influence ampicillin concentration in serum and tissues?
Eur J Drug Metab Pharmacokinet
; 26(3): 167-71, 2001.
Article
em En
| MEDLINE
| ID: mdl-11695716
ABSTRACT
Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels. Two groups of Wistar rats were used. Group A consisted of six subgroups that were subjected to cold swimming (4 degrees C) for 5, 10, 15, 20,25, 30 days respectively. Group B was the control group. The animals were injected im. with ampicillin (1 g/Kg/8h in 5 doses). Results showed that exercise enhanced stress parameters (FFAs, adrenal weight, Ht%) and led to an ampicillin increase in all experimental groups comparatively to controls.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilinas
/
Estresse Psicológico
/
Esforço Físico
/
Ampicilina
Limite:
Animals
Idioma:
En
Revista:
Eur J Drug Metab Pharmacokinet
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Grécia