Antiviral pathway activation in patients with chronic fatigue syndrome and acute infection.
Clin Infect Dis
; 33(12): 2080-1, 2001 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-11698994
ABSTRACT
Gene expression of key enzymes in 2 antiviral pathways (ribonuclease latent [RNase L] and RNA-regulated protein kinase [PKR]) was compared in 22 patients with chronic fatigue syndrome (CFS), 10 patients with acute gastroenteritis, and 21 healthy volunteers. Pathway activation in the group of patients with infections differed significantly from that of the other 2 groups, in whom there was no evidence of upregulation. Therefore, assay of activation is unlikely to provide the basis for a diagnostic test for CFS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Fadiga Crônica
/
EIF-2 Quinase
/
Endorribonucleases
/
Gastroenterite
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Reino Unido