Regarding the inadvisability of administering postoperative analgesics in the drinking water of rats (Rattus norvegicus).
Contemp Top Lab Anim Sci
; 40(6): 15-7, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11703050
ABSTRACT
The feasibility of administering the pain reliever acetaminophen to rats via their water bottles was examined in this study. Two different preparations of acetaminophen were used, a cherry-flavored suspension and an alcohol-containing solution. Both preparations of acetaminophen were diluted to 6 mg/ml by using normal drinking water. When healthy unmanipulated rats were exposed to either of the acetaminophen preparations for the first time, the animals showed a dramatic reduction in fluid intake. A marked reduction in food intake also was associated with the cherry-flavored preparation. These reductions appear to be an expression of the well-characterized neophobic response that can be demonstrated by rodents when they encounter a novel taste. This neophobic behavior suggests that administering pain relievers to rats via their drinking water is counterproductive as a means of providing pain relief.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Água
/
Anti-Inflamatórios não Esteroides
/
Comportamento de Ingestão de Líquido
/
Analgesia
/
Acetaminofen
Limite:
Animals
Idioma:
En
Revista:
Contemp Top Lab Anim Sci
Assunto da revista:
MEDICINA VETERINARIA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos