Effect of N-acetylcysteine on colitis induced by acetic acid in rats.
Gen Pharmacol
; 35(2): 77-81, 2000 Aug.
Article
em En
| MEDLINE
| ID: mdl-11707313
ABSTRACT
(1) To verify the proposed role of reactive oxygen species (ROS) in ulcerative colitis, the effect of an antioxidant N-acetylcysteine (NAC) was studied in acetic acid (AA)-induced colonic inflammation. (2) Depending on the dose used, NAC administered intracolonically was found to reduce the extent of colonic damage, along with a decrease in myeloperoxidase (MPO) activity, colonic wet weight and wet/dry weight ratio. (3) NAC attenuated the enhanced vascular permeability and prevented the depletion of colonic reduced glutathione (GSH) caused by AA administration. (4) The findings indicate that NAC may prove beneficial in the treatment of colitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilcisteína
/
Colite
Limite:
Animals
Idioma:
En
Revista:
Gen Pharmacol
Ano de publicação:
2000
Tipo de documento:
Article