[Comparative evaluation of neurovirulence of domestic and foreign live mumps vaccine]. / Sravnitel'naia otsenka neirovirulentnosti otechestvennoi i zarubezhnykh zhivykh parotitnykh vaktsin.

ABSTRACT

Morphological and immunofluorescent study of changes in the central nervous system of monkeys with mumps was carried out in order to determine the criteria of neurovirulence of different mumps virus strains. Quantitative evaluation showed a lower residual neurovirulence of L-3 strain vs. Jeryl Lynn and Urabe Am9 strains. Use of new methodological approaches to evaluation of mumps vaccine strain neurovirulence will improve the safety control of live mumps vaccines.