Ontogeny of the dendritic, and follicle-associated epithelial cells in the bursa of Fabricius of guinea fowl (Numida meleagris).
Ital J Anat Embryol
; 106(2 Suppl 1): 271-7, 2001.
Article
em En
| MEDLINE
| ID: mdl-11729965
ABSTRACT
A panel of monoclonal antibodies was produced to study the mesenchymal stromal elements of the bursa of Fabricius in guinea hen. The intracellular antigens recognized by GIIF3 and NIC2 monoclonal antibodies are of 50 and 30 kD, respectively. The cells identified by these antibodies emerge in the mesenchyme around day 12 of incubation, and immigrate into the surface epithelium of the bursal folds, which precedes the follicle formation. The GIIF3 cells move up to the luminal surface of the follicle and differentiate to follicle-associated epithelial cells. The NIC2 cells remain in the medulla, produce and secrete large amount NIC2 positive substance, when the bursal function starts up. The presence of double positive (GIIF3 and NIC2) cells in the medulla around hatching, seems to indicate, that the two cells might have a common origin. The NIC2 positive product of the bursal secretory dendritic cells contributes to the microenvironment, and possibly necessary for the B cell clonal expansion and establisment of the immune repertoire in the guinea hen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aves Domésticas
/
Bolsa de Fabricius
/
Diferenciação Celular
/
Células Estromais
/
Linhagem da Célula
/
Células Dendríticas Foliculares
/
Células Epiteliais
/
Mesoderma
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Ital J Anat Embryol
Assunto da revista:
ANATOMIA
/
EMBRIOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Hungria