Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization: a randomized, prospective study.
Fertil Steril
; 76(6): 1140-3, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11730741
ABSTRACT
OBJECTIVE:
To compare IVF outcome between two protocols for luteal phase supplementation, one beginning on day 3 after oocyte retrieval and the other beginning on day 6 after retrieval.DESIGN:
Prospective, randomized study.SETTING:
University-based assisted reproductive technology center. PATIENT(S) One hundred twenty-six consecutive patients undergoing IVF between January and July 2000. INTERVENTION(S) Patients were randomized to begin luteal phase support using vaginal progesterone beginning either on day 3 after oocyte retrieval or on day 6 after oocyte retrieval. MAIN OUTCOME MEASURE(S) Clinical pregnancy rates and implantation rates. RESULT(S) All patients randomized underwent transfer. There were no differences in age, oocytes retrieved, or embryos transferred between the two groups. Those patients receiving luteal phase support with progesterone beginning on day 6 after retrieval had a significantly lower clinical pregnancy rate per transfer compared with those beginning support on day 3 after retrieval (44.8% vs. 61.0%, respectively). This difference in pregnancy rates was greater in those patients undergoing a luteal gonadotropin releasing hormone (GnRH) agonist down-regulation protocol (47.5% vs. 71.4%, day 6 vs. day 3, respectively). Beginning support on day 6 also significantly decreased implantation rates in the GnRH agonist group (21.0% vs. 34.0%, day 6 vs. day 3, respectively). CONCLUSION(S) Pregnancy rates are significantly decreased by initiating luteal-phase progesterone supplementation on day 6 after oocyte retrieval during in vitro fertilization cycles.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Indução da Ovulação
/
Progesterona
/
Fertilização in vitro
Tipo de estudo:
Clinical_trials
/
Guideline
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos