Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides.
Biopolymers
; 60(3): 212-9, 2001.
Article
em En
| MEDLINE
| ID: mdl-11774227
ABSTRACT
The development of soluble mixture-based heterocyclic combinatorial libraries derived from amino acids and peptides is described. Starting with a "toolbox" of various chemical transformations, including alkylations, reductions, acylations, and the use of a variety of bifunctional reagents, the "libraries from libraries" concept has been expanded to encompass the development of more than fifty positional scanning combinatorial libraries each composed of tens of thousands of low molecular weight acyclic and heterocyclic compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese Peptídica
/
Peptídeos
Idioma:
En
Revista:
Biopolymers
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos