In vivo effects of phenolic compounds on blood parameters of a marine fish (Dicentrarchus labrax).
Comp Biochem Physiol C Toxicol Pharmacol
; 125(3): 345-53, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-11790355
ABSTRACT
Sea bass (Dicentrarchus labrax) were injected intraperitoneally once (single dose) or three times (fractionated dose) with phenol or OH-phenols (hydroquinone, resorcinol, and pyrocatechol). On the basis of the lethal doses, OH-phenols were more toxic than phenol, and pyrocatechol was the most powerful compound. Hematological, metabolic and antioxidant blood parameters were measured 3 days after the end of the treatment. Metabolic variations as specific effects on erythrocytes were revealed and differences between single and fractionated doses were observed. OH-phenols-treated fish showed disorders in the metabolic toxicity indicators as hypoglycemia, low blood urea nitrogen level (BUN) and decrease of alkaline phosphatase activity (ALP). In addition, quantitative structure-activity relationships were developed using the n-octanolwater partition coefficient (log K(ow)). Positive correlations were found with ALP, plasma glucose and hemoglobin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Quinidina
/
Glicemia
/
Bass
/
Hemoglobinas
/
Fosfatase Alcalina
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Toxicol Pharmacol
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
França