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Variations in biological features of West Nile viruses.
Deubel, V; Fiette, L; Gounon, P; Drouet, M T; Khun, H; Huerre, M; Banet, C; Malkinson, M; Desprès, P.
Afiliação
  • Deubel V; Institut Pasteur, Unité de Biologie des Infections Virales Emergentes, Lyon, France. vdeubel@cervi-lyon.inserm.fr
Ann N Y Acad Sci ; 951: 195-206, 2001 Dec.
Article em En | MEDLINE | ID: mdl-11797777
Pathological findings in humans, horses, and birds with West Nile (WN) encephalitis show neuronal degeneration and necrosis in the central nervous system (CNS), with diffuse inflammation. The mechanisms of WN viral penetration of the CNS and pathophysiology of the encephalitis remain largely unknown. Since 1996, several epizootics involving hundreds of humans, horses, and thousands of wild and domestic bird cases of encephalitis and mortality have been reported in Europe, North Africa, the Middle East, Russia, and the USA (see specific chapters in this issue). However, biological and molecular markers of virus virulence should be characterized to assess whether novel strains with increased virulence are responsible for this recent proliferation of outbreaks.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre do Nilo Ocidental / Vírus do Nilo Ocidental Limite: Animals / Humans Idioma: En Revista: Ann N Y Acad Sci Ano de publicação: 2001 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre do Nilo Ocidental / Vírus do Nilo Ocidental Limite: Animals / Humans Idioma: En Revista: Ann N Y Acad Sci Ano de publicação: 2001 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos