Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.
Eur J Med Chem
; 37(1): 3-10, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11841870
ABSTRACT
The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantridinas
/
Pirróis
/
Infecções por HIV
/
HIV-1
/
Fármacos Anti-HIV
Limite:
Humans
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Itália