Effects of growth hormone treatment on left ventricular dimensions in children with Noonan's syndrome.
Horm Res
; 56(3-4): 110-3, 2001.
Article
em En
| MEDLINE
| ID: mdl-11847472
ABSTRACT
OBJECTIVE:
To study the effects of long-term growth hormone (GH) treatment on left ventricular (LV) dimensions in children with Noonan's syndrome (NS).METHODS:
Echocardiographic measurements of LV dimensions were performed before and during GH treatment in 27 participants (21 boys, 6 girls) in a partly controlled 3-year trial of high-dose GH treatment (0.15 IU/kg/day). Nineteen children had a congenital heart defect, 1 of them had hypertrophic obstructive cardiomyopathy. In the first 3 years, the children were assigned to 1 of 2 groups group A with discontinuation of GH treatment in the 3rd year, or group B without GH treatment in the 1st year. After the 3rd year, 12 of the 27 children were followed up for 2 additional years to evaluate the long-term effects of GH treatment on the heart.RESULTS:
At baseline, LV internal diameters were smaller, while posterior wall thickness were thicker than normal. Over the 1st year, changes in LV dimensions were comparable between the 2 groups. No significant differences were found in LV dimensions between the situation at baseline and after 4 years of GH treatment.CONCLUSION:
Long-term high-dose GH treatment does not have clinically significant adverse effects on LV dimensions in children with NS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio do Crescimento
/
Ecocardiografia
/
Síndrome de Noonan
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Horm Res
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Holanda