Urinary tract calculi and thresholds in carcinogenesis.
Food Chem Toxicol
; 40(6): 793-9, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-11983274
ABSTRACT
Numerous chemicals administered to rodents at relatively high doses produce urinary tract calculi, resulting in erosions or ulcerations of the urothelium, consequent regenerative hyperplasia, and ultimately tumors. This is a high-dose (threshold) phenomenon, which appears to occur more readily in rodents than in primates, including humans. Several anatomic and urinary physiologic differences between rodents and humans affect the quantitative extrapolation from results in rodent bioassays to human risk assessment. For most chemicals producing tumors by this mode of action, human exposures are significantly lower than would be expected to be required for production of calculi, and therefore pose no carcinogenic hazard to humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálculos Urinários
/
Neoplasias Urológicas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos