Male siblings with dyserythropoiesis, microcephaly and intrauterine growth retardation.
Clin Dysmorphol
; 11(2): 107-11, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-12002139
ABSTRACT
Male siblings with intrauterine growth retardation, hydrops, mild liver dysfunction, chronic diarrhoea, failure to thrive and microcephaly are reported. In both patients, the intrauterine growth retardation was detected in the second trimester of pregnancy. Relatively severe early onset neonatal jaundice, microcytosis, anisocytosis and abnormal iron metabolism were also seen. Bone marrow examination in the second sibling showed marked ringed sideroblasts and multilobulated erythroblasts in late developmental stages. The brain was very small with enlarged cerebrospinal fluid space, a reduced number of gyri and a thin cortex. The clinical and laboratory findings in these patients appear to be unique.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retardo do Crescimento Fetal
/
Anemia Diseritropoética Congênita
/
Microcefalia
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Revista:
Clin Dysmorphol
Assunto da revista:
TERATOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Japão