TRPV3 is a calcium-permeable temperature-sensitive cation channel.
Nature
; 418(6894): 181-6, 2002 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-12077604
ABSTRACT
Transient receptor potential (TRP) proteins are cation-selective channels that function in processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are gated by heat and capsaicin (>43 degrees C; TRPV1 (ref. 1)), noxious heat (>52 degrees C; TRPV2 (ref. 2)), and cooling (< 22 degrees C; TRPM8 (refs 3, 4)) have been cloned; however, little is known about the molecular determinants of temperature sensing in the range between approximately 22 degrees C and 40 degrees C. Here we have identified a member of the vanilloid channel family, human TRPV3 (hTRPV3) that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain. Increasing temperature from 22 degrees C to 40 degrees C in mammalian cells transfected with hTRPV3 elevated intracellular calcium by activating a nonselective cationic conductance. As in published recordings from sensory neurons, the current was steeply dependent on temperature, sensitized with repeated heating, and displayed a marked hysteresis on heating and cooling. On the basis of these properties, we propose that hTRPV3 is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Temperatura
/
Ativação do Canal Iônico
/
Permeabilidade da Membrana Celular
/
Cálcio
/
Proteínas de Transporte de Cátions
/
Canais Iônicos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nature
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos