Impact of perioperative myocardial injury on early and long-term outcome after coronary artery bypass grafting.
Eur Heart J
; 23(15): 1219-27, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12127924
ABSTRACT
AIMS:
To establish the influence of perioperative myocardial injury on short- and long-term survival after coronary artery bypass grafting (CABG). METHODS ANDRESULTS:
The correlation of postoperative serum aspartate aminotransferase and creatine kinase MB to early cardiac-related death and to late survival was evaluated in 4911 patients who underwent CABG consecutively during a 6-year period. There were 93 early deaths (1.9%), 73 of them cardiac-related (1.5% of 4911). After a mean follow-up of 5 years, 409 additional deaths (8.5% of 4818) had occurred. Elevated enzyme levels on day 1 postoperatively highly increased the risk of early cardiac death (serum aspartate aminotransferase >or=2.35 microkat.l(-1) odds ratio 9.2; serum creatine kinase MB >or=61 microg.l(-1) odds ratio 6.0), and increased the risk of late death by approximately 50% (serum aspartate aminotransferase >or=2.35 microkat.l(-1) relative hazard 1.5; serum creatine kinase MB >or=61 microg.l(-1) relative hazard 1.4). This increased risk of death was independent of other risk factors and remained constant over time.CONCLUSIONS:
Enzyme elevation after CABG implied an increased risk of both early and late death. The long-term effect persisted many years after surgery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Ponte de Artéria Coronária
/
Traumatismos Cardíacos
/
Miocárdio
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Eur Heart J
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Suécia