Plasmodium-mosquito interactions, phage display libraries and transgenic mosquitoes impaired for malaria transmission.
Insect Biochem Mol Biol
; 32(10): 1325-31, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12225923
ABSTRACT
Malaria continues to kill millions of people every year and new strategies to combat this disease are urgently needed. Recent advances in the study of the mosquito vector and its interactions with the malaria parasite suggest that it may be possible to genetically manipulate the mosquito in order to reduce its vectorial capacity. Here we review the advances made to date in four areas (1) the introduction of foreign genes into the mosquito germ line; (2) the characterization of tissue-specific promoters; (3) the identification of gene products that block development of the parasite in the mosquito; and (4) the generation of transgenic mosquitoes impaired for malaria transmission. While initial results show great promise, the problem of how to spread the blocking genes through wild mosquito populations remains to be solved.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium
/
Insetos Vetores
/
Anopheles
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Insect Biochem Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos