[Action of heliomycin on the incorporation of labelled protein precursors and nucleic acid in Staphylococcus aureus cells]. / Deistvie geliomitsina na vkliuchenie mechenykh predshestvennikov belka i nukleinovykh kislot v kletki Staphylococcus aureus
Antibiotiki
; 20(6): 503-6, 1975 Jun.
Article
em Ru
| MEDLINE
| ID: mdl-1225201
ABSTRACT
In concentrations of 0.05-0.10 gamma/ml geliomycin suppresses inclusion of C14-uracyl into the acid-soluble fractions of the staphylococcal cells. Inclusion of C14-leucine at the same concentrations of the antibiotics was suppressed to a lesser extent. The above concentrations of geliomycin had practically no effect on inclusion of C14-thimine. Suppression of C14-uracyl inclusion was observed in 5 minutes of the cell incubation with the antibiotic, a significant decrease in C14-leucine inclusion being observed only in 30 minutes of the incubation. The effect of geliomycin on the staphylococcal cells within the concentrations inhibiting the microbial growth and suppressing inclusion of labeled uracyl and leucine into the cells was of the bacteriostatic nature. It was supposed that the antibacterial effect of geliomycin was based on suppression of RNA synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Staphylococcus aureus
/
DNA Bacteriano
/
RNA Bacteriano
/
Antibacterianos
Idioma:
Ru
Revista:
Antibiotiki
Ano de publicação:
1975
Tipo de documento:
Article