Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis.
Fertil Steril
; 78(4): 757-62, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12372452
ABSTRACT
OBJECTIVE:
To examine whether ultralong GnRH analog (GnRH-a) therapy after surgical treatment of endometriosis and before ART influences the pregnancy rate.DESIGN:
Prospective, randomized, controlled study.SETTING:
University clinic for reproductive medicine and gynecologic endocrinology. PATIENT(S) One hundred ten patients with stage II to IV endometriosis according to ASRM criteria. INTERVENTION(S) Fifty-five patients received GnRH-a for 6 months after surgery and subsequently underwent up to 3 cycles of ART, and 55 patients received 3 cycles of ART alone immediately after surgery. MAIN OUTCOME MEASURE(S) Clinical pregnancy rates.RESULTS:
The pregnancy rate per patient was higher among patients who received follow-up treatment with GnRH-a. The same results were found in patients with stage III or IV endometriosis who were undergoing IUI or IVF/ICSI. CONCLUSION(S) Ultralong GnRH-a therapy increases the pregnancy rate of ART in patients with severe endometriosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gosserrelina
/
Endometriose
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Alemanha