Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide.
Neurology
; 59(8): 1257-8, 2002 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-12391360
ABSTRACT
Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first evidence that statins in clinically relevant dosages indeed affect cerebral cholesterol metabolism. However, these changes were not associated with altered intrathecal secretion of Alzheimer Abeta.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Córtex Cerebral
/
Colesterol
/
Peptídeos beta-Amiloides
/
Doença de Alzheimer
/
Anticolesterolemiantes
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Alemanha