Turnover of synaptic membranes: age-related changes and modulation by dietary restriction.
J Neurosci Res
; 70(3): 290-7, 2002 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-12391588
ABSTRACT
We examined age-related changes in the turnover rates of synaptic membrane components that might underlie the decrease in synaptic functions in senescence. Synaptic membrane constituents were labeled in vivo with deuterium and the disappearance of the deuterated molecules from synaptic membranes was measured by mass spectrometry. The turnover rates of phosphatidylcholine, phosphatidylethanolamine, cholesterol, and synaptophysin were all shown to slow down with aging. Dietary restriction, which is known to retard various aging processes, was found to decrease the turnover rates of membrane lipid species. Consequently, the fatty acid composition in phospholipids remained unchanged in the synaptic plasma membranes of food restricted mice. In contrast, the turnover rate of synaptophysin was accelerated under dietary restriction. This may mean that increased turnover enhances the removal of damaged proteins from membranes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membranas Sinápticas
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Encéfalo
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Envelhecimento
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Doenças Neurodegenerativas
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Privação de Alimentos
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Lipídeos de Membrana
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Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Neurosci Res
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Japão