Bronchodilation in infants with malacia or recurrent wheeze.
Arch Dis Child
; 88(3): 246-9, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12598393
ABSTRACT
BACKGROUND:
Controversy remains regarding the effectiveness of bronchodilators in wheezy infants.AIMS:
To assess the effect of inhaled beta(2) agonists on lung function in infants with malacia or recurrent wheeze, and to determine whether a negative effect of beta(2) agonists on forced expiratory flow (V'(maxFRC)) is more pronounced in infants with airway malacia, compared to infants with wheeze.METHODS:
We retrospectively analysed lung function data of 27 infants eight with malacia, 19 with recurrent wheeze. Mean (SD) age was 51 (18) weeks. Mean V'(maxFRC) (in Z score) was assessed before and after inhalation of beta(2) agonists.RESULTS:
Baseline V'(maxFRC) was below reference values for both groups. Following inhalation of beta(2) agonists the mean (95% CI) change in mean V'(maxFRC) in Z scores was -0.10 (-0.26 to 0.05) and -0.33 (-0.55 to -0.11) for the malacia and wheeze group, respectively.CONCLUSIONS:
In infants with wheeze, inhaled beta(2) agonists caused a significant reduction in mean V'(maxFRC). Infants with malacia were not more likely to worsen after beta(2) agonists than were infants with recurrent wheeze.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Broncopatias
/
Broncodilatadores
/
Sons Respiratórios
/
Agonistas Adrenérgicos beta
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
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Infant
/
Male
Idioma:
En
Revista:
Arch Dis Child
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Holanda