[Preventive therapy for nausea and vomiting in patients on opioid therapy for non-malignant pain in rheumatology]. / Intérêt de la prévention des nausées et vomissements chez des patients traités par morphine pour des douleurs bénignes d'origine rhumatologique.
Therapie
; 57(5): 446-9, 2002.
Article
em Fr
| MEDLINE
| ID: mdl-12611198
ABSTRACT
OBJECTIVE:
To determine if systematic use of metoclopramide associated with opioids (Morphine sulfate SR) decreases the incidence of nausea and vomiting (N&V), established adverse effects of opioids.METHOD:
Open randomised study with 132 patients treated for non malignant pain (71 women, 61 men, mean age 53.4 years). One group (n = 76) was treated with morphine alone; the other (n = 56) with morphine plus metoclopramide. Mean duration of therapy 6 days; mean dosage 60 mg/dRESULTS:
In the 2 groups, N&V were present in the first 72 hours. The frequency of N&V in the morphine group was 38.1% (conform with the literature). The systematic use of metoclopramide decreases the frequency of N&V p < 0.005. However the use of morphine > 60 mg/d decreases N&V p = 0.036. High dosages of morphine can have an antiemetic effect by interaction with the mu receptors in the antiemetic center and not in the trigger zone which has an emetic effect.CONCLUSION:
The systematic use of metoclopramide with opioid therapy for non malignant pain in rheumatology decreases the risk of nausea and vomiting.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Vômito
/
Doenças Reumáticas
/
Analgésicos Opioides
/
Metoclopramida
/
Morfina
/
Antieméticos
/
Náusea
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Therapie
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
França