The development of COX2 inhibitors.
Nat Rev Drug Discov
; 2(3): 179-91, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12612644
ABSTRACT
Aspirin, arguably the world's favourite drug, has been around since the late nineteenth century, but it wasn't until the late 1970s that its ability to inhibit prostaglandin production by the cyclooxygenase enzyme was identified as the basis of its therapeutic action. Early hints of a second form of the cyclooxygenase that was differentially sensitive to other aspirin-like drugs ultimately ushered in an exciting era of drug discovery, culminating in the introduction of an entirely new generation of anti-inflammatories. This article reviews the story of this discovery and looks at the future of cyclooxygenase pharmacology.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Ciclo-Oxigenase
/
Prostaglandina-Endoperóxido Sintases
/
Isoenzimas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Drug Discov
Assunto da revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Reino Unido