Autologous stem cell transplantation and purging in adult acute lymphoblastic leukaemia.
Best Pract Res Clin Haematol
; 15(4): 675-93, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12617870
ABSTRACT
The prognosis for adult acute lymphoblastic leukaemia (ALL) is poor. Only 20-30% of patients will be cured with conventional chemotherapy. Haematopoietic progenitor transplantation is thus an attractive option in these patients. Even if allogeneic transplantation allows a better control of the disease, autologous transplantation remains an important alternative for patients lacking a suitable donor or when allogeneic transplants imply excessive risk. Relapse is the main drawback of autologous transplants, but many strategies are being explored to overcome this problem. We focus here on transplant modality, the source of haematopoietic progenitors, and the best timing to apply the procedure. Also reviewed are the current situation and future strategies for improving results in this setting, such as ex vivo purging; immunotherapy and maintenance chemotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Purging da Medula Óssea
/
Transplante de Células-Tronco Hematopoéticas
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Best Pract Res Clin Haematol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Espanha