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Detection and clinical significance of Ba2+- and Sr2+-dependent antiprothrombin antibodies in patients with systemic lupus erythematosus and antiphospholipid syndrome.
Sanaka, T; Matsuda, J; Teramoto, T.
Afiliação
  • Sanaka T; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Lupus ; 12(2): 117-23, 2003.
Article em En | MEDLINE | ID: mdl-12630756
We conducted this study to confirm whether or not Ca2+-dependent antiprothrombin antibody (aPT) in patients' sera with systemic lupus erythematosus and/or primary antiphospholipid syndrome would react to prothrombin/phosphatidylserine in the presence of Sr2+, Mn2+ or Ba2+, or divalent metal ions like Ca2+, utilizing ELISA, and to analyze the clinical significance of these metal-dependent aPT. We found the presence of Ba2+- and Sr2+-dependent IgG, IgM and IgA-aPT in up to 65% of patients negative for Ca2+-dependent IgG-, IgM and IgA-aPT. Maximally 69% of them were complicated by antiphospholipid syndrome-related symptoms. These data suggest that the measurement of Ba2+- and Sr2+- along with Ca2+-dependent aPT may become a clinically useful tool to correctly detect patients with antiphospholipid-related complications. However, further study is needed to clarify the clinicopathological differences among these aPTs in the future.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Protrombina / Síndrome Antifosfolipídica / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lupus Assunto da revista: REUMATOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Protrombina / Síndrome Antifosfolipídica / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lupus Assunto da revista: REUMATOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido