Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet.
Neurology
; 60(6): 1026-9, 2003 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-12654976
ABSTRACT
The authors analyzed blood metabolites in nine children with epilepsy prior to starting the ketogenic diet (KD) and 3 to 4 weeks after KD therapy. Elevated beta-hydroxybutyrate and cortisol levels were observed in all children on the KD. Free fatty acids increased 2.2-fold on the KD, with significant elevations in most polyunsaturated fatty acids (PUFA; arachidonate increased 1.6- to 2.9-fold and docosahexaenoate increased 1.5- to 4.0-fold). The rise in total serum arachidonate correlated with improved seizure control. Elevated PUFA may represent a key anticonvulsant mechanism of the KD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dieta
/
Epilepsia
/
Ácidos Graxos Insaturados
/
Cetonas
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Neurology
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Canadá