Effect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach.
Trop Gastroenterol
; 23(3): 122-4, 2002.
Article
em En
| MEDLINE
| ID: mdl-12693153
ABSTRACT
BACKGROUND:
Subsequent to esophagectomy and reconstruction among patients with esophageal cancers, the intrathoracic denervated stomach acts as a passive conduit without peristalsis.OBJECTIVE:
The study was designed to assess the impact of two prokinetic drugs viz. erythromycin and cisapride on the emptying of vagally denervated intrathoracic stomach.METHODS:
Twenty consecutive patients of carcinoma esophagus, who had undergone one stage transhiatal oesophagectomy with cervical esophagogastrostomy and were disease free at three months postoperative follow-up, were included in the study. These patients were randomised into two groups of ten each. The patients in group A received erythromycin, while patients in group B received cisapride. The gastric emptying was studied by scintigraphy, using a standard test meal containing 99m Tc sulphur colloid labelled 'IDLIS' [rice based radio labelled food] before and after the drug treatment.RESULTS:
The pre and post treatment mean gastric half emptying time of the patients in the erythromycin group was 52.6 min and 49.7 min (p > 0.1) and in cisapride group it was 53.76 and 26.4 min respectively (p < 0.05). Intergroup comparison of the difference was not statistically significant.CONCLUSION:
Cisapride is an effective prokinetic agent in the treatment of gastric stasis of the vagally denervated intrathoracic stomach.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estômago
/
Vagotomia
/
Fármacos Gastrointestinais
/
Neoplasias Esofágicas
/
Eritromicina
/
Esofagectomia
/
Cisaprida
/
Esvaziamento Gástrico
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Trop Gastroenterol
Ano de publicação:
2002
Tipo de documento:
Article
País de publicação:
IN
/
INDIA
/
ÍNDIA