Susceptibilities of simian immunodeficiency virus to protease inhibitors.
Antimicrob Agents Chemother
; 47(5): 1756-9, 2003 May.
Article
em En
| MEDLINE
| ID: mdl-12709355
ABSTRACT
We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means +/- standard deviations) of 39 +/- 8, 55 +/- 3, and 13 +/- 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 +/- 4, 47 +/- 10, and 25 +/- 14 nM, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Imunodeficiência Símia
/
Inibidores da Protease de HIV
Limite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos