[Nocardia cyriacigeorgici: First report of invasive human infection]. / Nocardia cyriacigeorgici: Erstbeschreibung als invasive Infektion.
Dtsch Med Wochenschr
; 128(19): 1038-41, 2003 May 09.
Article
em De
| MEDLINE
| ID: mdl-12736853
ABSTRACT
BACKGROUND:
Diagnostic laboratories increasingly offer bacterial identification to the species level. The 17 nocardia species known to date differ in their clinical presentation, antibiotic resistance patterns and geographic distribution. The discovery of a new species with pathogenicity for humans calls for the characterization of its clinical and epidemiological properties. PATIENTS ANDMETHODS:
Nocardia isolated from multifocal brain abscesses of an immunocompromised patient were further identified by the analysis of their cellular fatty acids and sequencing of the 16S ribosomal DNA. Quantitative antibiotic resistance testing was performed with E-tests.RESULTS:
The 16S ribosomal DNA analysis showed a 99 % homology to Nocardia cyriacigeorgici. This is the first report of this species as an invasive human pathogen. N. cyriacigeorgici was found susceptible for meropenem, amikacin, ceftriaxon and cotrimoxazole. The combination of surgical drainage and antibiotic treatment for 13 months was curative.CONCLUSIONS:
N. cyriacigeorgici has the potential to cause invasive infections at least in immunocompromised patients. Comparing clinical and in vitro characteristics with N. asteroides, the main causative agent of nocardial infections in Europe, we found no clinically relevant differences.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Abscesso Encefálico
/
Hospedeiro Imunocomprometido
/
Antibacterianos
/
Nocardia
/
Nocardiose
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Dtsch Med Wochenschr
Ano de publicação:
2003
Tipo de documento:
Article