Syntheses and ultraviolet absorption of aza-steroids.
Steroids
; 27(2): 225-34, 1976 Feb.
Article
em En
| MEDLINE
| ID: mdl-1273888
ABSTRACT
A series of aza-steroids was synthesized containing chromophoric groups, such as a, beta-unsaturated ketones and doubly unsaturated conjugated and monoconjugated heteroannular dienones with the heteroatom in the D ring at the 20 and 17a positions. The effect of an appositely placed electronegative center in these molecules upon their ultraviolet absorptions was studied. In order to obtain a basis for the observed spectral changes, the corresponding carbocyclic compounds were also synthesized. The maximum absorptions of the aza-steroids were hypsochromically shifted relative to the carbocyclic compounds in all cases (n=8). The displacement caused by the electronegative center on absorption maximum of the chromophores is, however, highly dependent on its location within the molecules.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides Heterocíclicos
/
Azasteroides
Idioma:
En
Revista:
Steroids
Ano de publicação:
1976
Tipo de documento:
Article