The interaction of metal ions and Marimastat with matrix metalloproteinase 9.
J Inorg Biochem
; 95(2-3): 165-70, 2003 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-12763661
ABSTRACT
The effect of a range of metal ions on the ability of Marimastat to inhibit matrix metalloproteinase 9 (MMP-9) was examined in a fluorescence based proteolytic assay. Whilst none of the metals examined significantly affected the inhibitory ability of Marimastat, several metal ions did have a significant effect on MMP-9 activity itself. In the absence of Marimastat, Zn(II) and Fe(II) significantly inhibited MMP-9 activity at metal ion concentrations of 10 and 100 microM, respectively. In both the absence and presence of Marimastat, Cd(II) significantly inhibited MMP-9 at 100 microM. In contrast, 1 mM Co(II) significantly upregulated MMP-9 proteolytic activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metais Pesados
/
Inibidores Enzimáticos
/
Inibidores de Metaloproteinases de Matriz
/
Ácidos Hidroxâmicos
Limite:
Humans
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2003
Tipo de documento:
Article