[Role of neuraminidase in pathogenesis of influenza]. / Rol' neiraminidazy v patogeneze grippozonoi infektsii.

ABSTRACT

The influenza neuraminidase (NA) possesses, both in vivo and in vitro, the anticoagulant and fibrinolytic activity. A computerized comparative analysis of the influenza NA viruses, type A, showed nine regions of amino-acid sequences compatible with the tissue activator of human plasminogen. The mentioned regions are highly conservative for each NA subtype irrespective of a source or a year, when an influenza strain was isolated. The role of NA in pathogenesis of influenza infection is under consideration.