[Microvascular reactivity in type 2 diabetes mellitus and its relation to IGF-I and its binding proteins]. / Reaktivita mikrocirkulace u diabetes mellitus 2. typu a její vztah k systému IGF-I a jeho vazebných proteinu.
Vnitr Lek
; 49(7): 535-40, 2003 Jul.
Article
em Cs
| MEDLINE
| ID: mdl-12931435
BACKGROUND AND AIM: System of insulin-like growth factor-I (IGF-I) and its binding proteins (IGFBP) may be involved in the pathogenesis of vascular damage in Type 2 diabetes. Aim of the study was to analyse the relationship between this system and microvascular reactivity in Type 2 diabetes as measured by laser-Doppler flowmetry. METHODS AND RESULTS: Thirteen Type 2 diabetic patients (8 women and 5 men) with microangiopathy and fifteen healthy subjects (8 women and 7 men) were examined clinically, underwent laser-Doppler flowmetry and intima-media thickness measurements. Fasting serum levels of IGF-I, IGFBP and lipids were examined. Percentage perfusion increase in the test with postocclusive reactive hyperaemia (PORH) as well as in that with thermal hyperaemia (TH) were significantly decreased in Type 2 diabetic patients (p < 0.05). Maximal perfusion after heating (THmax) was lower in Type 2 diabetic patients. Reaction of microcirculation after heating (THmax/t) was slower in Type 2 diabetic patients (p < 0.001). The changes in microvascular reactivity didn't significantly correlate with any of measured parameters of IGF-I/IGFBP system. CONCLUSIONS: Microvascular reactivity is impaired in Type 2 diabetic patients. The function of microcirculation is not significantly related to the particular parameters of the IGF-I/IGFBP system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina
/
Diabetes Mellitus Tipo 2
/
Angiopatias Diabéticas
/
Microcirculação
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Cs
Revista:
Vnitr Lek
Ano de publicação:
2003
Tipo de documento:
Article
País de publicação:
República Tcheca