[The production of IL-2, IL-6 in relation to the functional development of NK cells in human fetal spleens].
Shi Yan Sheng Wu Xue Bao
; 25(4): 305-9, 1992 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-1303001
ABSTRACT
The production of IL-2, IL-6 by fetal splenic mononuclear cells (FSMC) and relationship between them and the ontogenetic development of natural killer cell function were studied in human fetal spleens. As a results, before 20 weeks of gestation, both IL-2 and NK cell activities were not measured, but IL-6 was done. It was found that IL-2, IL-6 and NK cell activities were increased with the gestational age, and shown that there were linear positive correlation between the activities of three ones above (r > 0.86). Before the birth, the induced IL-2 activity was the same as adult levels (p > 0.05), although both IL-6 production and NK activity in fetal spleens were significantly lower than that in adults (p < 0.01). Lastly, the production of IL-2, IL-6 in relation to the functional development of NK cells during the embryonic development was discussed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Células Matadoras Naturais
/
Interleucina-6
/
Interleucina-2
Limite:
Adult
/
Humans
Idioma:
Zh
Revista:
Shi Yan Sheng Wu Xue Bao
Ano de publicação:
1992
Tipo de documento:
Article