Alterations of prostaglandin E2-9-ketoreductase activity in proliferating skin.
J Lipid Res
; 18(1): 37-43, 1977 Jan.
Article
em En
| MEDLINE
| ID: mdl-13133
ABSTRACT
The activity of an NADPH-dependent PGE2-9-ketoreductase has been demonstrated in rat and human skin. This activity is localized in the high speed supernatant fraction, indicating the presence of an active PGE2-9-ketoreductase associated with the cytoplasmic fraction of the skin. Transformation of PGE2 into PGF2alpha is enhanced by skin specimens from psoriatic plaques and EFA-deficient rats, both characterized by excessive cellular proliferation and increased NADPH production. Incubations of the 105,000 g supernatant fractions from normal and EFA-deficient rats demonstrated that the activity of the PGE2-9-ketoreductase was elevated in high speed preparations from EFA-deficient rats. Results from these studies suggest that the increased activity of PGE2-9-ketoreductase observed in skin from human psoriatic plaques and EFA-deficient rats may be due in part to the increased generation of NADPH by these tissues and in part to alteration of the PGE2-9-ketoreductase by the excessive proliferation of the tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Ácidos Graxos Essenciais
/
Hidroxiprostaglandina Desidrogenases
/
Oxirredutases do Álcool
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Lipid Res
Ano de publicação:
1977
Tipo de documento:
Article