Genetic complementation analysis of two independently isolated hycanthone-resistant strains of Schistosoma mansoni.
Mem Inst Oswaldo Cruz
; 87 Suppl 4: 211-4, 1992.
Article
em En
| MEDLINE
| ID: mdl-1343897
ABSTRACT
The objective of this study is to determine whether various hycanthone resistant strains of schistosomes which have been independently isolated are all affected in the same gene. A strain obtained from a Brazilian patient was compared with a strain of Puerto Rican origin selected in the laboratory. If the mutation conferring resistance involved two different genes, one would expect that progeny of a cross between the two strains would show complementation, i.e. it would be sensitive to the drug. We have performed such a cross and obtained F1 hybrid worms which were essentially all resistant, thus suggesting that the mutation conferring resistance in the two strains involves the same gene.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Schistosoma mansoni
/
Genes de Helmintos
/
Hicantone
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
/
Caribe
/
Puerto rico
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália