Randomized, double-blind, crossover, placebo-controlled comparison of propranolol and betaxolol in the treatment of neuroleptic-induced akathisia.
Am J Psychiatry
; 149(5): 647-50, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1349458
ABSTRACT
OBJECTIVE:
Beta-blocking agents, particularly propranolol, are considered effective in the treatment of neuroleptic-induced akathisia, but considerable controversy exists about the involved receptor subtype(s). The authors conducted a randomized, controlled trial comparing the effects of propranolol and betaxolol to determine whether central beta 1-adrenoceptor blockade is sufficient to correct neuroleptic-induced akathisia.METHOD:
The subjects were 19 patients whose neuroleptic-induced akathisia responded to 20 mg/day of propranolol and subsequently reemerged during a placebo washout period. They were randomly assigned to propranolol (20 or 40 mg/day) or betaxolol (10 or 20 mg/day) and, after another placebo period, were switched to the second beta blocker.RESULTS:
There was no significant difference in the antiakathisia effects of propranolol and betaxolol.CONCLUSIONS:
The lack of difference between propranolol and betaxolol suggests that beta 1-adrenoceptor blockade is sufficient to improve neuroleptic-induced akathisia. The results of this explanatory study need therapeutic confirmation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Agitação Psicomotora
/
Antipsicóticos
/
Betaxolol
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França