Use of nonoxynol-9 and reduction in rate of gonococcal and chlamydial cervical infections.
Lancet
; 339(8806): 1371-5, 1992 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-1350804
ABSTRACT
The spermicide nonoxynol-9 (N-9) has been used as a contraceptive for over 30 years, but the use of a vaginal spermicide and condoms for the prevention of sexually transmitted infections has not been examined in randomised studies. We report a single-blind randomised field trial to assess the effect of N-9 film on the rate of gonococcal and chlamydial cervical infection in women at high risk of these diseases. 343 women were randomly assigned to use either condoms and N-9 (186 women) or condoms and a placebo (157). Compliance with condom use was much the same in the two groups. Overall, N-9 reduced the rate of cervical infection by 25% (rate ratio [RR] 0.75, 95% confidence interval [Cl] 0.5-1.1); in women who used N-9 for more than 75% of their coital acts the infection rate was reduced by 40% (RR 95% Cl 0.3-1.0). The rate of yeast vulvovaginitis or genital ulcers was not higher in N-9 users than in placebo users, but the rate of symptomatic irritation was increased by 70% (RR 95% Cl 1.1-2.6) among N-9 users. Condom use was more protective against cervical infection than N-9 use. The rate of infection was 50% (RR 95% Cl 0.3-0.7) lower with 75% than with 0-50% condom compliance. The use of a vaginal N-9 spermicide with condoms whenever possible seems to be a better strategy than the use of condoms only for prevention of gonococcal and chlamydial cervical infection.
Palavras-chave
Asia; Barrier Methods; Behavior; Biology; Cervical Effects; Cervix; Chlamydia--prevention and control; Comparative Studies; Condom; Contraception; Contraceptive Agents--therapeutic use; Contraceptive Effectiveness; Contraceptive Methods; Contraceptive Usage; Control Groups; Data Analysis; Demographic Factors; Developing Countries; Diseases; Family Planning; Genitalia; Genitalia, Female; Gonorrhea--prevention and control; Hiv Infections--prevention and control; Infections; Method Acceptability; Multiple Partners; Nonoxynol-9--therapeutic use; Physiology; Population; Reproductive Tract Infections; Research Methodology; Risk Factors; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Southeastern Asia; Spermicidal Contraceptive Agents--therapeutic use; Studies; Thailand; Urogenital System; Use-effectiveness; Uterus; Viral Diseases
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Espermicidas
/
Infecções por Chlamydia
/
Gonorreia
/
Doenças do Colo do Útero
/
Chlamydia trachomatis
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Lancet
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Tailândia