Penetration of fimbriate enteric bacteria through basement membranes: a hypothesis.
FEMS Microbiol Lett
; 100(1-3): 307-12, 1992 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-1362172
ABSTRACT
A mechanism for penetration of basement membranes by Escherichia coli is presented. The mechanism is based on the ability of the S fimbriae of meningitis-associated E. coli to bind to vascular endothelium and choroid plexuses in brain and to basement membranes. On the other hand, the S and the type 1 fimbriae of E. coli immobilize plasminogen and tissue-type plasminogen activator; this process generates proteolytic plasmin activity on the surface of fimbriate cells. Our hypothesis is that bacterium-bound plasma activity, directed to basement membranes through fimbrial binding, promotes bacterial penetration through basement membranes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Basal
/
Enterobacteriaceae
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Finlândia