Immunomodulatory effects of gamma-HCH (Lindane) in mice.
Immunopharmacol Immunotoxicol
; 14(1-2): 261-82, 1992.
Article
em En
| MEDLINE
| ID: mdl-1375957
ABSTRACT
Mice were fed for 24 weeks with three different subtoxic dosages of gamma-HCH (0.012, 0.12 and 1.2 mg/kg) mixed in powdered feed. The immunological profile was assessed at an interval of one month during the entire exposure period. Both the cell mediated and humoral components of immunity showed a biphasic response characterized initially by stimulation followed by suppression in a dose dependent manner. However, gamma-HCH did not affect the functional properties of peritoneal macrophages. Histological changes in lymphoid organs were in accordance with the biphasic immunomodulatory effects of gamma-HCH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hexaclorocicloexano
/
Sistema Imunitário
Limite:
Animals
Idioma:
En
Revista:
Immunopharmacol Immunotoxicol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Índia