Inhibition of mutagenesis by p-aminobenzoic acid as a nitrite scavenger.
Mutat Res
; 282(2): 119-25, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1377350
ABSTRACT
Nitrite treatment enhances the direct-acting mutagenicity of various foodstuffs (e.g., chicken, bloater, the soybean flour 'kinako', and Ban-Ban-Chi sauce) on Salmonella typhimurium TA100. p-Aminobenzoic acid (PABA) and glutathione (GSH) reduced this mutagenicity; on the other hand, thioproline (TPRO) increased it. PABA seemed more effective than TPRO in scavenging nitrite ion. In analysis of the reactions of PABA and sodium nitrite under acidic conditions (pH 3.0), p-hydroxybenzoic acid (PHBA) was identified as a major reaction product. The reaction seems to involve two steps, diazotization and diazonium substitution. PHBA was not mutagenic to four strains (TA97, TA98, TA100 and TA102) of S. typhimurium with or without S9 mix.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Ácido 4-Aminobenzoico
/
Mutagênese
/
Glutationa
/
Nitritos
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Japão