Regional cerebral glucose metabolism and attention in adults with a history of childhood autism.
J Neuropsychiatry Clin Neurosci
; 4(4): 406-14, 1992.
Article
em En
| MEDLINE
| ID: mdl-1422167
ABSTRACT
Sixteen high-functioning adults with a history of childhood autism and 26 normal control subjects underwent [18F]fluoro-2-deoxyglucose positron-emission tomography to assess regional cerebral glucose metabolic rate (GMR). Autistic patients had a left > right anterior rectal gyrus asymmetry, as opposed to the normal right > left asymmetry in that region. Patients also showed low GMR in the left posterior putamen and high GMR in the right posterior calcarine cortex. Brain regions with GMR > 3 SD from the normal mean were more prevalent in patients than in control subjects. This variable pattern of abnormal activity is consistent with heterogeneous neurophysiological etiology; group differences in striatum and cortex may represent a final common pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atenção
/
Transtorno Autístico
/
Glicemia
/
Encéfalo
/
Tomografia Computadorizada de Emissão
/
Dominância Cerebral
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuropsychiatry Clin Neurosci
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
1992
Tipo de documento:
Article