Pharmacodynamics and tolerability of L-654,066, a steroid 5 alpha-reductase inhibitor, in men.
Clin Pharmacol Ther
; 52(4): 409-12, 1992 Oct.
Article
em En
| MEDLINE
| ID: mdl-1424413
ABSTRACT
A four-period, two-panel single rising-dose study (0.1 to 100 mg) was conducted in healthy men to investigate the pharmacodynamics and tolerability of L-654,066, a steroid 5 alpha-reductase inhibitor. Within each panel, six subjects received L-654,066 and two subjects received placebo at each dose level; the placebo subjects changed between periods so that each subject received placebo once. Testosterone and dihydrotestosterone were measured in serum at 0, 4, 24, and 48 hours after each treatment. L-654,066 was associated with a significant reduction in serum dihydrotestosterone concentrations, which was maximal at 48 hours after dose. Forty-eight hours after treatment, mean percentage of inhibition was 24% and 39% for the 0.1 and 0.5 mg doses, respectively, and ranged from 50% to 65% at doses from 1 to 25 mg and from 70% to 75% at doses from 50 to 100 mg. Testosterone serum levels did not show any significant difference between the various treatments, including placebo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azasteroides
/
Inibidores de 5-alfa Redutase
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Bélgica